Neurobiology of Disease Normal Midbrain Dopaminergic Neuron Development and Function in miR-133b Mutant Mice
نویسندگان
چکیده
Mary P. Heyer,1,2 Amar K. Pani,3 Richard J. Smeyne,3 Paul J. Kenny,2 and Guoping Feng1,4 1Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, 2Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Florida, Jupiter, Florida 33458, 3Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, and 4McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
منابع مشابه
Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice.
Midbrain dopaminergic (mDA) neurons control movement and emotion, and their degeneration leads to motor and cognitive defects in Parkinson's disease (PD). miR-133b is a conserved microRNA that is thought to regulate mDA neuron differentiation by targeting Pitx3, a transcription factor required for appropriate development of mDA substantia nigra neurons. Moreover, miR-133b has been found to be d...
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